Lead Bioinformatician

Company: Arinale Biosciences, Inc.
Location: Astoria
Posted on: January 6, 2026

Job Description:

Job: Lead Bioinformatician Arinale Biosciences Incorporated Arinale Biosciences is a biotechnology startup operating in stealth mode after having been recently spun out of one of New York City’s premier academic medical centers. Occupying a unique position at the nexus of scientific discovery and healthcare, Arinale’s platform for rapid development of paradigm-changing therapeutics will extend the benefits of precision oncology far beyond current limitations and fundamentally improve the health of cancer patients with limited treatment options. By utilizing cutting-edge science with an unwavering commitment to patients, we’re helping create a future where every diagnosis is clearer, every decision is more confident, and every life has a better chance/more hope. Mission Guided by vision, powered by innovation, and grounded in compassion, we will catalyze the discovery and development of a new generation of transformative cancer therapies. Role We are seeking a lead bioinformatician to establish robust interpretative frameworks for novel NGS-based assays. A successful candidate will integrate with experimental and computational teams, collaborating on experimental design, data pipeline development, and conceptually lead and implement data analysis and interpretation. Ideal candidates will have a strong engineering mindset, excited to build analysis workflows from the ground up and enjoy the creative challenge of decoding information-rich datasets into actionable insights. Responsibilities - Plan, develop, and execute reusable pipelines for processing NGS data Benchmark and evaluate alternative data processing procedures - Conceptualize, design, and implement a robust interpretation framework Identify and integrate multiomic data to inform data interpretation - Generate reports/dashboards for data QC metrics and interpretive readouts - Collaborate with experimentalists on experimental design and protocol optimization - Communicate results (oral, written) to colleagues, collaborators, and stakeholders - Manage and advise junior associates - Maintain knowledge of state-of-the-art methodologies and best practices Requirements - PhD in Bioinformatics, Computational Biology, Systems Biology, or related field - In-depth experience with NGS data processing (e.g., RNA-seq, ChIP/CLIP-seq, CRISPR screens, peak calling) - Fundamental understanding of mRNA lifecycle and associated experimental assays - Mastery of core statistical and ML procedures for normalization, differential analysis, dimensionality reduction, and clustering - Knowledge of statistical power analyses for experimental design - Strong interdisciplinary communication skills - Fluency in Unix and scripting languages (e.g., Python, R) - Experience with version-control and writing technical documentation Standout Experiences - Additional postdoctoral or industry experience - Complex (heterogenous) data integrations for functional insights - Factor analysis for signal decomposition (e.g., NMF, model or VAE-based methods) - DNN or other ML methodologies for sequence-to-profile (coverage, expression) modeling, with a focus on de novo feature identification - Specialized expertise in mRNA-protein interactions and associated assays - Pipeline development with a workflow language (e.g., Nextflow, Snakemake) - Advanced experimental design procedures (e.g., Bayesian optimization, AIHITL) - Cloud computing (GCP, AWS) and/or HPC (SLURM, LSF) - Schema design and database management for cataloguing datasets

Keywords: Arinale Biosciences, Inc., Stratford , Lead Bioinformatician, IT / Software / Systems , Astoria, Connecticut